[HTML][HTML] Metabolomics in psoriatic disease: pilot study reveals metabolite differences in psoriasis and psoriatic arthritis

AW Armstrong, J Wu, MA Johnson, D Grapov… - …, 2014 - ncbi.nlm.nih.gov
AW Armstrong, J Wu, MA Johnson, D Grapov, B Azizi, J Dhillon, O Fiehn
F1000Research, 2014ncbi.nlm.nih.gov
Importance: While “omics” studies have advanced our understanding of inflammatory skin
diseases, metabolomics is mostly an unexplored field in dermatology. Objective: We sought
to elucidate the pathogenesis of psoriatic diseases by determining the differences in
metabolomic profiles among psoriasis patients with or without psoriatic arthritis and healthy
controls. Design: We employed a global metabolomics approach to compare circulating
metabolites from patients with psoriasis, psoriasis and psoriatic arthritis, and healthy …
Abstract
Importance: While “omics” studies have advanced our understanding of inflammatory skin diseases, metabolomics is mostly an unexplored field in dermatology.
Objective: We sought to elucidate the pathogenesis of psoriatic diseases by determining the differences in metabolomic profiles among psoriasis patients with or without psoriatic arthritis and healthy controls.
Design: We employed a global metabolomics approach to compare circulating metabolites from patients with psoriasis, psoriasis and psoriatic arthritis, and healthy controls.
Setting: Study participants were recruited from the general community and from the Psoriasis Clinic at the University of California Davis in United States.
Participants: We examined metabolomic profiles using blood serum samples from 30 patients age and gender matched into three groups: 10 patients with psoriasis, 10 patients with psoriasis and psoriatic arthritis and 10 control participants.
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