Recent studies have shown that acute intermittent hypoxia (IH) induces sensory plasticity of
the carotid body manifested as sensory long-term facilitation (LTF), which requires prior
conditioning with chronic IH and is mediated by reactive oxygen species (ROS). The
purpose of this article is to provide a brief review of chronic IH-induced sensory LTF of the
carotid body, sources of ROS, mechanisms underlying sensory LTF and its functional
significance. Development of sensory LTF requires conditioning with several days of chronic …