OSA is a common chronic disorder that is associated with significant morbidity and mortality
including cardiovascular, metabolic, and neurocognitive disease and increased cancer-
related deaths. OSA is characterized by recurrent episodes of apneas and hypopneas
associated with repetitive episodes of intermittent hypoxemia, intrathoracic pressure
changes, and arousals. Intermittent hypoxemia (IH) is now being recognized as a potential
major factor contributing to the pathogenesis of OSA-related comorbidities. OSA-related high …