Tumor necrosis factor–related apoptosis inducing ligand (TRAIL) is an important
immunomodulatory factor that may play a role in the structural changes observed in the
asthmatic airways. In vitro as well as in vivo studies have evidenced a dual role for TRAIL: it
can either function as a pro-or anti-inflammatory cytokine on inflammatory cells, participating
in the initiation and resolution of inflammatory and immune responses. TRAIL is expressed
in the airways by inflammatory cells infiltrated in the bronchial mucosa, as well as by …