[HTML][HTML] Transcriptional activation of the p21WAF1, CIP1, SDI1 gene by interleukin-6 type cytokines: a prerequisite for their pro-differentiating and anti-apoptotic effects …
T Bellido, CA O'Brien, PK Roberson… - Journal of Biological …, 1998 - ASBMB
The cyclin-dependent kinase inhibitor p21 WAF1, CIP1, SDI1 plays a critical role in cell
differentiation, and it has been shown to confer resistance to apoptosis. Based on this, and
on evidence that activation of the gp130/signal transducer and activator of transcription
(STAT) signal transduction pathway by interleukin (IL)-6 type cytokines promotes
differentiation and prevents apoptosis in osteoblastic cells, we have investigated the
possibility that p21 is a downstream effector of this signaling pathway in osteoblasts. We …
differentiation, and it has been shown to confer resistance to apoptosis. Based on this, and
on evidence that activation of the gp130/signal transducer and activator of transcription
(STAT) signal transduction pathway by interleukin (IL)-6 type cytokines promotes
differentiation and prevents apoptosis in osteoblastic cells, we have investigated the
possibility that p21 is a downstream effector of this signaling pathway in osteoblasts. We …