Derivation of enriched oligodendrocyte cultures and oligodendrocyte/neuron myelinating co-cultures from post-natal murine tissues
RW O'Meara, SD Ryan, H Colognato… - JoVE (Journal of …, 2011 - jove.com
Identifying the molecular mechanisms underlying OL development is not only critical to
furthering our knowledge of OL biology, but also has implications for understanding the
pathogenesis of demyelinating diseases such as Multiple Sclerosis (MS). Cellular
development is commonly studied with primary cell culture models. Primary cell culture
facilitates the evaluation of a given cell type by providing a controlled environment, free of
the extraneous variables that are present in vivo. While OL cultures derived from rats have …
furthering our knowledge of OL biology, but also has implications for understanding the
pathogenesis of demyelinating diseases such as Multiple Sclerosis (MS). Cellular
development is commonly studied with primary cell culture models. Primary cell culture
facilitates the evaluation of a given cell type by providing a controlled environment, free of
the extraneous variables that are present in vivo. While OL cultures derived from rats have …