[HTML][HTML] Protective role of transient pore openings in calcium handling by cardiac mitochondria
Long-lasting mitochondrial permeability transition pore (mPTP) openings damage
mitochondria, but transient mPTP openings protect against chronic cardiac stress. To probe
the mechanism, we subjected isolated cardiac mitochondria to gradual Ca 2+ loading,
which, in the absence of BSA, induced long-lasting mPTP opening, causing matrix
depolarization. However, with BSA present to mimic cytoplasmic fatty acid-binding proteins,
the mitochondrial population remained polarized and functional, even after matrix Ca 2+ …
mitochondria, but transient mPTP openings protect against chronic cardiac stress. To probe
the mechanism, we subjected isolated cardiac mitochondria to gradual Ca 2+ loading,
which, in the absence of BSA, induced long-lasting mPTP opening, causing matrix
depolarization. However, with BSA present to mimic cytoplasmic fatty acid-binding proteins,
the mitochondrial population remained polarized and functional, even after matrix Ca 2+ …