Mitochondrial biochemical lesion and pyrogenic effect of pentachlorophenol

P Buffa, E Carafoli, U Muscatello - Biochemical Pharmacology, 1963 - Elsevier
P Buffa, E Carafoli, U Muscatello
Biochemical Pharmacology, 1963Elsevier
The biochemical activity of mitochondria isolated from liver of pentachlorophenol (PCP)-
injected rats were studied before, during, and after the appearance of the hyperthermia
produced by the compound. PCP was found to provoke in liver mitochondria definite
biochemical lesions, already apparent 15 sec after PCP administration. The damage was
revealed by a lowering of the P: O ratios, the loss of the respiratory control, the increase of
the oxidation rate towards some substrates, and the increase of the latent ATPase activity …
Abstract
The biochemical activity of mitochondria isolated from liver of pentachlorophenol (PCP)-injected rats were studied before, during, and after the appearance of the hyperthermia produced by the compound. PCP was found to provoke in liver mitochondria definite biochemical lesions, already apparent 15 sec after PCP administration. The damage was revealed by a lowering of the P:O ratios, the loss of the respiratory control, the increase of the oxidation rate towards some substrates, and the increase of the latent ATPase activity. The return of liver mitochondria to the conditions of controls occurred gradually and lagged largely behind the return of the body temperature to the normal values. The results are discussed in relation to the genesis of the hyperthermia produced by PCP.
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