The IL-20 subfamily of cytokines—from host defence to tissue homeostasis

S Rutz, X Wang, W Ouyang - Nature Reviews Immunology, 2014 - nature.com
S Rutz, X Wang, W Ouyang
Nature Reviews Immunology, 2014nature.com
Abstract The interleukin-20 (IL-20) subfamily of cytokines comprises IL-19, IL-20, IL-22, IL-24
and IL-26. These cytokines are all members of the larger IL-10 family, but have been
grouped together to form the IL-20 subfamily based on their usage of common receptor
subunits and similarities in their target-cell profiles and biological functions. Members of the
IL-20 subfamily facilitate the communication between leukocytes and epithelial cells, thereby
enhancing innate defence mechanisms and tissue repair processes at epithelial surfaces. In …
Abstract
The interleukin-20 (IL-20) subfamily of cytokines comprises IL-19, IL-20, IL-22, IL-24 and IL-26. These cytokines are all members of the larger IL-10 family, but have been grouped together to form the IL-20 subfamily based on their usage of common receptor subunits and similarities in their target-cell profiles and biological functions. Members of the IL-20 subfamily facilitate the communication between leukocytes and epithelial cells, thereby enhancing innate defence mechanisms and tissue repair processes at epithelial surfaces. In this Review, we describe the cellular sources and targets of the IL-20 subfamily cytokines, and we detail how their expression is regulated. Much of our understanding of the unique biology of this group of cytokines is still based on IL-22, which is the most studied member of the IL-20 subfamily. Nevertheless, we attempt a broader discussion of the emerging functions of IL-20 subfamily cytokines in host defence, inflammatory diseases, cancer and metabolism.
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