Toll-like receptor-4 signaling and Kupffer cells play pivotal roles in the pathogenesis of non-alcoholic steatohepatitis
CA Rivera, P Adegboyega, N van Rooijen… - Journal of …, 2007 - Elsevier
BACKGROUND/AIMS: Studies in animal models and humans suggest a link between
endotoxemia and non-alcoholic steatohepatitis. Since Kupffer cells are responsible for
clearing endotoxin and are activated via endotoxin interaction with Toll-like receptor 4 (TLR-
4), we examined the relationship between hepatic TLR-4 expression and Kupffer cell
content during the genesis of steatohepatitis. METHODS: Male C57BL/6, C3H/HouJ and
TLR-4 mutant C3H/HeJ mice were fed control or methionine/choline-deficient diet (MCDD) …
endotoxemia and non-alcoholic steatohepatitis. Since Kupffer cells are responsible for
clearing endotoxin and are activated via endotoxin interaction with Toll-like receptor 4 (TLR-
4), we examined the relationship between hepatic TLR-4 expression and Kupffer cell
content during the genesis of steatohepatitis. METHODS: Male C57BL/6, C3H/HouJ and
TLR-4 mutant C3H/HeJ mice were fed control or methionine/choline-deficient diet (MCDD) …