[HTML][HTML] The Mcm2–7-interacting domain of human mini-chromosome maintenance 10 (Mcm10) protein is important for stable chromatin association and origin firing
M Izumi, T Mizuno, K Yanagi, K Sugimura… - Journal of Biological …, 2017 - ASBMB
The protein mini-chromosome maintenance 10 (Mcm10) was originally identified as an
essential yeast protein in the maintenance of mini-chromosome plasmids. Subsequently,
Mcm10 has been shown to be required for both initiation and elongation during
chromosomal DNA replication. However, it is not fully understood how the multiple functions
of Mcm10 are coordinated or how Mcm10 interacts with other factors at replication forks.
Here, we identified and characterized the Mcm2–7-interacting domain in human Mcm10 …
essential yeast protein in the maintenance of mini-chromosome plasmids. Subsequently,
Mcm10 has been shown to be required for both initiation and elongation during
chromosomal DNA replication. However, it is not fully understood how the multiple functions
of Mcm10 are coordinated or how Mcm10 interacts with other factors at replication forks.
Here, we identified and characterized the Mcm2–7-interacting domain in human Mcm10 …