Immune perturbations in HIV-1–infected individuals who make broadly neutralizing antibodies

MA Moody, I Pedroza-Pacheco, NA Vandergrift… - Science …, 2016 - science.org
MA Moody, I Pedroza-Pacheco, NA Vandergrift, C Chui, KE Lloyd, R Parks, KA Soderberg…
Science immunology, 2016science.org
Induction of broadly neutralizing antibodies (bnAbs) is a goal of HIV-1 vaccine development.
bnAbs occur in some HIV-1–infected individuals and frequently have characteristics of
autoantibodies. We have studied cohorts of HIV-1–infected individuals who made bnAbs
and compared them with those who did not do so, and determined immune traits associated
with the ability to produce bnAbs. HIV-1–infected individuals with bnAbs had a higher
frequency of blood autoantibodies, a lower frequency of regulatory CD4+ T cells, a higher …
Induction of broadly neutralizing antibodies (bnAbs) is a goal of HIV-1 vaccine development. bnAbs occur in some HIV-1–infected individuals and frequently have characteristics of autoantibodies. We have studied cohorts of HIV-1–infected individuals who made bnAbs and compared them with those who did not do so, and determined immune traits associated with the ability to produce bnAbs. HIV-1–infected individuals with bnAbs had a higher frequency of blood autoantibodies, a lower frequency of regulatory CD4+ T cells, a higher frequency of circulating memory T follicular helper CD4+ cells, and a higher T regulatory cell level of programmed cell death–1 expression compared with HIV-1–infected individuals without bnAbs. Thus, induction of HIV-1 bnAbs may require vaccination regimens that transiently mimic immunologic perturbations in HIV-1–infected individuals.
AAAS