[HTML][HTML] Early painful diabetic neuropathy is associated with differential changes in the expression and function of vanilloid receptor 1
S Hong, JW Wiley - Journal of Biological Chemistry, 2005 - ASBMB
Diabetes mellitus is associated with one or more kinds of stimulus-evoked pain including
hyperalgesia and allodynia. The mechanisms underlying painful diabetic neuropathy remain
poorly understood. Previous studies demonstrate an important role of vanilloid receptor 1
(VR1) in inflammation and injury-induced pain. Here we investigated the function and
expression of VR1 in dorsal root ganglion (DRG) neurons isolated from streptozotocin-
induced diabetic rats between 4 and 8 weeks after onset of diabetes. DRG neurons from …
hyperalgesia and allodynia. The mechanisms underlying painful diabetic neuropathy remain
poorly understood. Previous studies demonstrate an important role of vanilloid receptor 1
(VR1) in inflammation and injury-induced pain. Here we investigated the function and
expression of VR1 in dorsal root ganglion (DRG) neurons isolated from streptozotocin-
induced diabetic rats between 4 and 8 weeks after onset of diabetes. DRG neurons from …