Background Evidence of a protective role of autophagy in kidney diseases has sparked
interest in autophagy as a potential therapeutic strategy. However, understanding how the
autophagic process is altered in each disorder is critically important in working toward
therapeutic applications. Methods Using cultured kidney proximal tubule epithelial cells
(PTECs) and diabetic mouse models, we investigated how autophagic activity differs in type
1 versus type 2 diabetic nephropathy. We explored nutrient signals regulating starvation …