Orexins/hypocretins in the ob/ob mouse: hypothalamic gene expression, peptide content and metabolic effects
A Stricker-Krongrad, S Richy, B Beck - Regulatory peptides, 2002 - Elsevier
Orexins (forms A and B) belong to a new family of peptides that, as neuropeptide Y (NPY),
stimulate food intake when centrally injected. The ob/ob mouse is a well-characterized
model of hyperphagia and obesity associated with strong metabolic disturbances and a
central dysregulation of peptides involved in the control of feeding. In the present report, we
investigated the hypocretin (Hcrt)/orexin (OX) peptide pathway in lean and ob/ob mice.
Prepro-Hcrt/OX mRNA expression, measured by in situ hybridization was restricted to the …
stimulate food intake when centrally injected. The ob/ob mouse is a well-characterized
model of hyperphagia and obesity associated with strong metabolic disturbances and a
central dysregulation of peptides involved in the control of feeding. In the present report, we
investigated the hypocretin (Hcrt)/orexin (OX) peptide pathway in lean and ob/ob mice.
Prepro-Hcrt/OX mRNA expression, measured by in situ hybridization was restricted to the …