Fibroblast growth factor receptor 4 regulates proliferation, anti-apoptosis and alpha-fetoprotein secretion during hepatocellular carcinoma progression and represents …
BACKGROUND/AIMS: FGFR4, a member of the fibroblast growth factor receptor family, has
been recently associated with progression of melanoma, breast and head and neck
carcinoma. Given its uniquely high expression in the liver, we investigated its contributory
role to hepatocellular carcinoma (HCC). METHODS: We performed a comprehensive
sequencing of full-length FGFR4 transcript in 57 tumor/normal HCC tissue pairs, and
quantified their mRNA expressions. Notable mutations and expression patterns were …
been recently associated with progression of melanoma, breast and head and neck
carcinoma. Given its uniquely high expression in the liver, we investigated its contributory
role to hepatocellular carcinoma (HCC). METHODS: We performed a comprehensive
sequencing of full-length FGFR4 transcript in 57 tumor/normal HCC tissue pairs, and
quantified their mRNA expressions. Notable mutations and expression patterns were …