Anorexia is a common symptom in chronic illness. It contributes to malnutrition and strongly
affects survival and quality of life. A common denominator of many chronic diseases is an
elevated inflammatory status, which is considered to play a pivotal role in the failure of food-
intake regulating systems in the hypothalamus. In this review, we summarize findings on the
role of hypothalamic inflammation on food intake regulation involving hypothalamic
neuropeptide Y (NPY) and pro-opiomelanocortin (POMC). Furthermore, we outline the role …