A pegylated leptin antagonist ameliorates CKD-associated cachexia in mice
WW Cheung, W Ding, SS Gunta, Y Gu… - Journal of the …, 2014 - journals.lww.com
Elevated serum leptin levels correlate with inflammation and predict changes in lean body
mass in patients with CKD, and activation of the melanocortin system by leptin signaling
mediates the pathophysiology of CKD-associated cachexia. We tested whether treatment
with a pegylated leptin receptor antagonist (PLA) attenuates cachexia in mice with CKD.
CKD and Sham mice received vehicle or PLA (2 or 7 mg/kg per day). At these doses, PLA
did not influence serum leptin levels in mice. Treatment with 7 mg/kg per day PLA stimulated …
mass in patients with CKD, and activation of the melanocortin system by leptin signaling
mediates the pathophysiology of CKD-associated cachexia. We tested whether treatment
with a pegylated leptin receptor antagonist (PLA) attenuates cachexia in mice with CKD.
CKD and Sham mice received vehicle or PLA (2 or 7 mg/kg per day). At these doses, PLA
did not influence serum leptin levels in mice. Treatment with 7 mg/kg per day PLA stimulated …
