Background Krabbe disease is a lysosomal disorder that primarily affects myelin. Diffusion
tensor imaging (DTI) provides quantitative information about the white matter organization
and integrity. Radial diffusivity (RD) reflects myelin injury selectively. Purpose To report on
quantitative DTI findings (including axial diffusivity (AD) and RD, not previously reported) in
two children with Krabbe disease compared to controls. Methods A quantitative region of
interest (ROI) based DTI analysis was performed for the patients and age-and gender …