MRI and electrophysiological abnormalities in a case of canine globoid cell leucodystrophy

F Cozzi, CH Vite, DA Wenger, T Victoria… - Journal of small …, 1998 - Wiley Online Library
F Cozzi, CH Vite, DA Wenger, T Victoria, ME Haskins
Journal of small animal practice, 1998Wiley Online Library
A six‐month‐old West Highland white terrier with progressive, multifocal neurological
disease was diagnosed with canine globoid cell leucodystrophy (GCL). Magnetic resonance
imaging (MRI) of the brain was performed, as well as electrophysiological testing (including
brainstem auditory evoked response, peripheral nerve conduction velocity, repetitive
stimulation, F wave analysis and electromyography). MRI findings were consistent with
diffuse, symmetrical white matter disease. Electrodiagnostic testing revealed evidence of …
A six‐month‐old West Highland white terrier with progressive, multifocal neurological disease was diagnosed with canine globoid cell leucodystrophy (GCL). Magnetic resonance imaging (MRI) of the brain was performed, as well as electrophysiological testing (including brainstem auditory evoked response, peripheral nerve conduction velocity, repetitive stimulation, F wave analysis and electromyography). MRI findings were consistent with diffuse, symmetrical white matter disease. Electrodiagnostic testing revealed evidence of peripheral neuropathy and an abnormal brainstem auditory evoked response. These observations were consistent with the pathological changes in central and peripheral white matter described for canine GCL, and resembled what has been described in human patients. It is believed that the tests may raise the suspicion of GCL in dogs and may aid in monitoring disease progression.
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