[HTML][HTML] ATP-binding cassette transporter A7 (ABCA7) loss of function alters Alzheimer amyloid processing
K Satoh, S Abe-Dohmae, S Yokoyama… - Journal of Biological …, 2015 - ASBMB
The ATP-binding cassette transporter A7 (ABCA7) has been identified as a susceptibility
factor of late onset Alzheimer disease in genome-wide association studies. ABCA7 has
been shown to mediate phagocytosis and affect membrane trafficking. The current study
examined the impact of ABCA7 loss of function on amyloid precursor protein (APP)
processing and generation of amyloid-β (Aβ). Suppression of endogenous ABCA7 in
several different cell lines resulted in increased β-secretase cleavage and elevated Aβ …
factor of late onset Alzheimer disease in genome-wide association studies. ABCA7 has
been shown to mediate phagocytosis and affect membrane trafficking. The current study
examined the impact of ABCA7 loss of function on amyloid precursor protein (APP)
processing and generation of amyloid-β (Aβ). Suppression of endogenous ABCA7 in
several different cell lines resulted in increased β-secretase cleavage and elevated Aβ …