[HTML][HTML] Tpl2 (tumor progression locus 2) phosphorylation at Thr290 is induced by lipopolysaccharide via an Iκ-B kinase-β-dependent pathway and is required for Tpl2 …
J Cho, M Melnick, GP Solidakis, PN Tsichlis - Journal of Biological …, 2005 - ASBMB
The serine-threonine protein kinase encoded by the tumor progression locus 2 (Tpl2) proto-
oncogene transduces Toll-like receptor and death receptor signals in a variety of cell types.
Here we show that Tpl2 undergoes phosphorylation at Thr 290 both in cells overexpressing
Tpl2 and in cells stimulated with lipopolysaccharide (LPS) or tumor necrosis factor-α and
that phosphorylation on this site parallels Tpl2 activation. Reconstitution of Tpl2–/–
macrophages with wild type Tpl2 or Tpl2 T290D restored ERK activation by LPS, whereas …
oncogene transduces Toll-like receptor and death receptor signals in a variety of cell types.
Here we show that Tpl2 undergoes phosphorylation at Thr 290 both in cells overexpressing
Tpl2 and in cells stimulated with lipopolysaccharide (LPS) or tumor necrosis factor-α and
that phosphorylation on this site parallels Tpl2 activation. Reconstitution of Tpl2–/–
macrophages with wild type Tpl2 or Tpl2 T290D restored ERK activation by LPS, whereas …