Inhibition of Tpl2 kinase and TNF-α production with 1, 7-naphthyridine-3-carbonitriles: Synthesis and structure–activity relationships
LK Gavrin, N Green, Y Hu, K Janz, N Kaila… - Bioorganic & medicinal …, 2005 - Elsevier
LK Gavrin, N Green, Y Hu, K Janz, N Kaila, HQ Li, SY Tam, JR Thomason, A Gopalsamy…
Bioorganic & medicinal chemistry letters, 2005•ElsevierThe synthesis and structure–activity studies of a series of 6-substituted-4-anilino-[1, 7]-
naphthyridine-3-carbonitriles as inhibitors of Tpl2 kinase are described. The early
exploratory work described here may lead to the discovery of compounds with significant
therapeutic potential for treating rheumatoid arthritis and other inflammatory diseases.
naphthyridine-3-carbonitriles as inhibitors of Tpl2 kinase are described. The early
exploratory work described here may lead to the discovery of compounds with significant
therapeutic potential for treating rheumatoid arthritis and other inflammatory diseases.
The synthesis and structure–activity studies of a series of 6-substituted-4-anilino-[1,7]-naphthyridine-3-carbonitriles as inhibitors of Tpl2 kinase are described. The early exploratory work described here may lead to the discovery of compounds with significant therapeutic potential for treating rheumatoid arthritis and other inflammatory diseases.
Elsevier