IL-36 signaling facilitates activation of the NLRP3 inflammasome and IL-23/IL-17 axis in renal inflammation and fibrosis

HH Chi, KF Hua, YC Lin, CL Chu… - Journal of the …, 2017 - journals.lww.com
IL-36 cytokines are proinflammatory and have an important role in innate and adaptive
immunity, but the role of IL-36 signaling in renal tubulointerstitial lesions (TILs), a major
prognostic feature of renal inflammation and fibrosis, remains undetermined. In this study,
increased IL-36α expression detected in renal biopsy specimens and urine samples from
patients with renal TILs correlated with renal function impairment. We confirmed the
increased expression of IL-36α in the renal tubular epithelial cells of a mouse model of …