An IL-17–dominant immune profile is shared across the major orphan forms of ichthyosis
AS Paller, Y Renert-Yuval, M Suprun, H Esaki… - Journal of Allergy and …, 2017 - Elsevier
Background The ichthyoses are rare genetic disorders associated with generalized scaling,
erythema, and epidermal barrier impairment. Pathogenesis-based therapy is largely lacking
because the underlying molecular basis is poorly understood. Objective We sought to
characterize molecularly cutaneous inflammation and its correlation with clinical and barrier
characteristics. Methods We analyzed biopsy specimens from 21 genotyped patients with
ichthyosis (congenital ichthyosiform erythroderma, n= 6; lamellar ichthyosis, n= 7; …
erythema, and epidermal barrier impairment. Pathogenesis-based therapy is largely lacking
because the underlying molecular basis is poorly understood. Objective We sought to
characterize molecularly cutaneous inflammation and its correlation with clinical and barrier
characteristics. Methods We analyzed biopsy specimens from 21 genotyped patients with
ichthyosis (congenital ichthyosiform erythroderma, n= 6; lamellar ichthyosis, n= 7; …