The Bruton's tyrosine kinase inhibitor acalabrutinib protects from anaphylaxis in a humanized mouse model
MC Dispenza, RA Krier-Burris… - Journal of Allergy and …, 2019 - jacionline.org
Methods NSG-SGM3 mice were engrafted with human CD34+ cells at age 3-4 weeks. 16
weeks after engraftment, passive systemic anaphylaxis (PSA) was induced by intravenous
sensitization with human anti-NP-IgE and challenge 24 hours later with intravenous injection
of NP-BSA. Mice were pre-treated with acalabrutinib or vehicle control via oral gavage prior
to challenge. Anaphylactic responses were assessed using core body temperature and
clinical scoring. Results NSG-SGM3 mice engrafted with human CD34+ cells showed good …
weeks after engraftment, passive systemic anaphylaxis (PSA) was induced by intravenous
sensitization with human anti-NP-IgE and challenge 24 hours later with intravenous injection
of NP-BSA. Mice were pre-treated with acalabrutinib or vehicle control via oral gavage prior
to challenge. Anaphylactic responses were assessed using core body temperature and
clinical scoring. Results NSG-SGM3 mice engrafted with human CD34+ cells showed good …