[HTML][HTML] Alternative splicing of MEF2C pre-mRNA controls its activity in normal myogenesis and promotes tumorigenicity in rhabdomyosarcoma cells
M Zhang, B Zhu, J Davie - Journal of Biological Chemistry, 2015 - ASBMB
Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children. Many
cellular disruptions contribute to the progression of this pediatric cancer, including aberrant
alternative splicing. The MEF2 family of transcription factors regulates many developmental
programs, including myogenesis. MEF2 gene transcripts are subject to alternate splicing to
generate protein isoforms with divergent functions. We found that MEF2Cα1 was the
ubiquitously expressed isoform that exhibited no myogenic activity and that MEF2Cα2, the …
cellular disruptions contribute to the progression of this pediatric cancer, including aberrant
alternative splicing. The MEF2 family of transcription factors regulates many developmental
programs, including myogenesis. MEF2 gene transcripts are subject to alternate splicing to
generate protein isoforms with divergent functions. We found that MEF2Cα1 was the
ubiquitously expressed isoform that exhibited no myogenic activity and that MEF2Cα2, the …