[HTML][HTML] Diet-induced lethality due to deletion of the Hdac3 gene in heart and skeletal muscle
Z Sun, N Singh, SE Mullican, LJ Everett, L Li… - Journal of Biological …, 2011 - ASBMB
Many human diseases result from the influence of the nutritional environment on gene
expression. The environment interacts with the genome by altering the epigenome,
including covalent modification of nucleosomal histones. Here, we report a novel and
dramatic influence of diet on the phenotype and survival of mice in which histone
deacetylase 3 (Hdac3) is deleted postnatally in heart and skeletal muscle. Although
embryonic deletion of myocardial Hdac3 causes major cardiomyopathy that reduces …
expression. The environment interacts with the genome by altering the epigenome,
including covalent modification of nucleosomal histones. Here, we report a novel and
dramatic influence of diet on the phenotype and survival of mice in which histone
deacetylase 3 (Hdac3) is deleted postnatally in heart and skeletal muscle. Although
embryonic deletion of myocardial Hdac3 causes major cardiomyopathy that reduces …