[HTML][HTML] The Transcription Factor TEAD1 Represses Smooth Muscle-specific Gene Expression by Abolishing Myocardin Function*♦
The TEAD (transcriptional enhancer activator domain) proteins share an evolutionarily
conserved DNA-binding TEA domain, which binds to the MCAT cis-acting regulatory
element. Previous studies have shown that TEAD proteins are involved in regulating the
expression of smooth muscle α-actin. However, it remains undetermined whether TEAD
proteins play a broader role in regulating expression of other genes in vascular smooth
muscle cells. In this study, we show that the expression of TEAD1 is significantly induced …
conserved DNA-binding TEA domain, which binds to the MCAT cis-acting regulatory
element. Previous studies have shown that TEAD proteins are involved in regulating the
expression of smooth muscle α-actin. However, it remains undetermined whether TEAD
proteins play a broader role in regulating expression of other genes in vascular smooth
muscle cells. In this study, we show that the expression of TEAD1 is significantly induced …