Mathematical modeling of the insulin signal transduction pathway for prediction of insulin sensitivity from expression data

CK Ho, L Rahib, JC Liao, G Sriram… - Molecular genetics and …, 2015 - Elsevier
Mathematical models of biological pathways facilitate a systems biology approach to
medicine. However, these models need to be updated to reflect the latest available
knowledge of the underlying pathways. We developed a mathematical model of the insulin
signal transduction pathway by expanding the last major previously reported model and
incorporating pathway components elucidated since the original model was reported.
Furthermore, we show that inputting gene expression data of key components of the insulin …