[HTML][HTML] The histone chaperone Spt6 is required for activation-induced cytidine deaminase target determination through H3K4me3 regulation
NA Begum, A Stanlie, M Nakata, H Akiyama… - Journal of Biological …, 2012 - ASBMB
H3K4me3 plays a critical role in the activation-induced cytidine deaminase (AID)-induced
DNA cleavage of switch (S) regions in the immunoglobulin heavy chain (IgH) locus during
class-switch recombination (CSR). The histone chaperone complex facilitates chromatin
transcription (FACT) is responsible for forming H3K4me3 at AID target loci. Here we show
that the histone chaperone suppressor of Ty6 (Spt6) also participates in regulating
H3K4me3 for CSR and for somatic hypermutation in AID target loci. We found that H3K4me3 …
DNA cleavage of switch (S) regions in the immunoglobulin heavy chain (IgH) locus during
class-switch recombination (CSR). The histone chaperone complex facilitates chromatin
transcription (FACT) is responsible for forming H3K4me3 at AID target loci. Here we show
that the histone chaperone suppressor of Ty6 (Spt6) also participates in regulating
H3K4me3 for CSR and for somatic hypermutation in AID target loci. We found that H3K4me3 …