Effect of duloxetine on pain, function, and quality of life among patients with chemotherapy-induced painful peripheral neuropathy: a randomized clinical trial
EML Smith, H Pang, C Cirrincione, S Fleishman… - Jama, 2013 - jamanetwork.com
Importance There are no known effective treatments for painful chemotherapy-induced
peripheral neuropathy. Objective To determine the effect of duloxetine, 60 mg daily, on
average pain severity. Design, Setting, and Patients Randomized, double-blind, placebo-
controlled crossover trial at 8 National Cancer Institute (NCI)–funded cooperative research
networks that enrolled 231 patients who were 25 years or older being treated at community
and academic settings between April 2008 and March 2011. Study follow-up was completed …
peripheral neuropathy. Objective To determine the effect of duloxetine, 60 mg daily, on
average pain severity. Design, Setting, and Patients Randomized, double-blind, placebo-
controlled crossover trial at 8 National Cancer Institute (NCI)–funded cooperative research
networks that enrolled 231 patients who were 25 years or older being treated at community
and academic settings between April 2008 and March 2011. Study follow-up was completed …