[HTML][HTML] Dysregulation of proinflammatory versus anti-inflammatory human TH17 cell functionalities in the autoinflammatory Schnitzler syndrome
R Noster, HD de Koning, E Maier, M Prelog… - Journal of Allergy and …, 2016 - Elsevier
Background TH 17 cells have so far been considered to be crucial mediators of autoimmune
inflammation. Two distinct types of TH 17 cells have been described recently, which differed
in their polarization requirement for IL-1β and in their cytokine repertoire. Whether these
distinct TH 17 phenotypes translate into distinct TH 17 cell functions with implications for
human health or disease has not been addressed yet. Objective We hypothesized the
existence of proinflammatory and anti-inflammatory human TH 17 cell functions based on …
inflammation. Two distinct types of TH 17 cells have been described recently, which differed
in their polarization requirement for IL-1β and in their cytokine repertoire. Whether these
distinct TH 17 phenotypes translate into distinct TH 17 cell functions with implications for
human health or disease has not been addressed yet. Objective We hypothesized the
existence of proinflammatory and anti-inflammatory human TH 17 cell functions based on …