Characterization of monocyte subtypes regarding their phenotype and development in the context of graft-versus-host disease
K Reinhardt-Heller, I Hirschberg, T Vogl… - Transplant …, 2018 - Elsevier
Graft-versus-host disease (GvHD) is a major cause of morbidity and mortality after
allogeneic hematopoietic cell transplantation (HCT). In this study, monocyte subtypes were
characterized regarding cytokine expression pattern and development in the context of
GvHD. Using inflammatory S100 proteins for monocyte stimulation, it could be demonstrated
that intermediate monocytes are the main producers of inflammatory cytokines such as IL-6
and TNFα known to be involved in the development of Th17 cells pointing towards an …
allogeneic hematopoietic cell transplantation (HCT). In this study, monocyte subtypes were
characterized regarding cytokine expression pattern and development in the context of
GvHD. Using inflammatory S100 proteins for monocyte stimulation, it could be demonstrated
that intermediate monocytes are the main producers of inflammatory cytokines such as IL-6
and TNFα known to be involved in the development of Th17 cells pointing towards an …