Enhanced clearance of a multiple antibiotic resistant Staphylococcus aureus in rats treated with PGG-glucan is associated with increased leukocyte counts and …

J Liang, D Melican, L Cafro, G Palace, L Fisette… - International journal of …, 1998 - Elsevier
PGG-Glucan [Betafectin®], a highly purified soluble β-(1–6)-branched β-(1–3)-linked glucan
isolated from Saccharomyces cerevisiae, has broad in vitro and in vivo anti-infective
activities unrelated to cytokine induction. Here we present in vivo results on the anti-infective
activity of PGG-Glucan against a multiple antibiotic resistant Staphylococcus aureus. PGG-
Glucan (0.25–4 mg⧹ kg) was administered intramuscularly to male Wistar rats 48 h, 24 h,
and 4 h before and 4 h after intraperitoneal implantation of a gelatin capsule containing …