[HTML][HTML] The inflammasomes

K Schroder, J Tschopp - cell, 2010 - cell.com
K Schroder, J Tschopp
cell, 2010cell.com
Inflammasomes are molecular platforms activated upon cellular infection or stress that
trigger the maturation of proinflammatory cytokines such as interleukin-1β to engage innate
immune defenses. Strong associations between dysregulated inflammasome activity and
human heritable and acquired inflammatory diseases highlight the importance this pathway
in tailoring immune responses. Here, we comprehensively review mechanisms directing
normal inflammasome function and its dysregulation in disease. Agonists and activation …
Summary
Inflammasomes are molecular platforms activated upon cellular infection or stress that trigger the maturation of proinflammatory cytokines such as interleukin-1β to engage innate immune defenses. Strong associations between dysregulated inflammasome activity and human heritable and acquired inflammatory diseases highlight the importance this pathway in tailoring immune responses. Here, we comprehensively review mechanisms directing normal inflammasome function and its dysregulation in disease. Agonists and activation mechanisms of the NLRP1, NLRP3, IPAF, and AIM2 inflammasomes are discussed. Regulatory mechanisms that potentiate or limit inflammasome activation are examined, as well as emerging links between the inflammasome and pyroptosis and autophagy.
cell.com