Reply: Capgras syndrome: neuroanatomical assessment of brain MRI findings in an adolescent patient

RR Darby, MD Fox - Brain, 2017 - academic.oup.com
Brain, 2017academic.oup.com
We generated a map of brain regions where strokes would be predicted to result in
delusional misidentifications. To generate this map, we created a 4 mm radius spherical
region of interest centred at peak region of positive connectivity (right ventral frontal cortex,
MNI coordinates x= 54, y= 14, z= 10) and negative connectivity (left retrosplenial cortex, MNI
coordinates x= 6, y= 56, z= 12) from our prior study of lesioninduced delusional
misidentifications (Darby et al., 2017). Functional connectivity maps for each region of …
We generated a map of brain regions where strokes would be predicted to result in delusional misidentifications. To generate this map, we created a 4 mm radius spherical region of interest centred at peak region of positive connectivity (right ventral frontal cortex, MNI coordinates x= 54, y= 14, z= 10) and negative connectivity (left retrosplenial cortex, MNI coordinates x= 6, y= 56, z= 12) from our prior study of lesioninduced delusional misidentifications (Darby et al., 2017). Functional connectivity maps for each region of interest were generated and combined to identify voxels both positively correlated with the right ventral frontal cortex and anti-correlated with the left retrosplenial cortex at a threshold of t> 4.25, P< 0.00005 uncorrected (Fig. 1). Based on our original report (Darby et al., 2017), lesion locations causing delusional misidentifications should fall within this ‘delusional misidentification network’.
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