Disinhibition syndromes, ranging from mildly inappropriate social behavior to full blown
mania, may result from lesions to specific brain areas. Several studies in patients with closed
head injuries, brain tumors, stroke lesions, and focal epilepsy have demonstrated a
significant association between disinhibition syndromes and dysfunction of orbitofrontal and
basotemporal cortices of the right hemisphere. Based on the phylogenetic origin of these
cortical areas and their main connections with dorsal regions related to visuospatial …