[HTML][HTML] Drosophila melanogaster mini spindles TOG3 utilizes unique structural elements to promote domain stability and maintain a TOG1-and TOG2-like tubulin …
AE Howard, JC Fox, KC Slep - Journal of Biological Chemistry, 2015 - ASBMB
Microtubule-associated proteins regulate microtubule (MT) dynamics spatially and
temporally, which is essential for proper formation of the bipolar mitotic spindle. The
XMAP215 family is comprised of conserved microtubule-associated proteins that use an
array of tubulin-binding tumor overexpressed gene (TOG) domains, consisting of six (A–F)
Huntingtin, elongation factor 3, protein phosphatase 2A, target of rapamycin (HEAT) repeats,
to robustly increase MT plus-end polymerization rates. Recent work showed that TOG …
temporally, which is essential for proper formation of the bipolar mitotic spindle. The
XMAP215 family is comprised of conserved microtubule-associated proteins that use an
array of tubulin-binding tumor overexpressed gene (TOG) domains, consisting of six (A–F)
Huntingtin, elongation factor 3, protein phosphatase 2A, target of rapamycin (HEAT) repeats,
to robustly increase MT plus-end polymerization rates. Recent work showed that TOG …