N-acetyl cysteine pre-treatment attenuates inflammatory changes in the warm ischemic murine lung
N Geudens, C Van De Wauwer, AP Neyrinck… - The Journal of heart and …, 2007 - Elsevier
BACKGROUND: The warm ischemic period in non–heart-beating donor lungs may
contribute to a higher degree of ischemia–reperfusion injury after lung transplantation. We
investigated the impact and timing of administration of N-acetyl cysteine (NAC) on
inflammatory parameters. METHODS: Ischemia (I) was induced by clamping the hilum of the
left lung for 90 minutes, and some protocols were followed by reperfusion (R) for 4 hours.
Mice were divided into nine groups (n= 6/group): three control groups ([sham](thoracotomy …
contribute to a higher degree of ischemia–reperfusion injury after lung transplantation. We
investigated the impact and timing of administration of N-acetyl cysteine (NAC) on
inflammatory parameters. METHODS: Ischemia (I) was induced by clamping the hilum of the
left lung for 90 minutes, and some protocols were followed by reperfusion (R) for 4 hours.
Mice were divided into nine groups (n= 6/group): three control groups ([sham](thoracotomy …