The bulk of endogenously produced IgG2a is eliminated from the serum of adult C57BL/6 mice with a half‐life of 6–8 days
P Vieira, K Rajewsky - European journal of immunology, 1986 - Wiley Online Library
P Vieira, K Rajewsky
European journal of immunology, 1986•Wiley Online LibraryThe concentration of IgG2a in the serum of C57BL/6 mice suppressed for the production of
IgG2a was measured over a period of 3 months after suppression. The elimination of a
minimum of 96% of the endogenous IgG2a molecules from the serum follows an exponential
decay with a half‐life of 6–8 days. A monoclonal IgG2a antibody injected into suppressed or
normal mice is eliminated from the serum in the same fashion. We conclude that there are
few, if any,“long‐lived” IgG2a molecules present in the serum of C57BL/6 mice under …
IgG2a was measured over a period of 3 months after suppression. The elimination of a
minimum of 96% of the endogenous IgG2a molecules from the serum follows an exponential
decay with a half‐life of 6–8 days. A monoclonal IgG2a antibody injected into suppressed or
normal mice is eliminated from the serum in the same fashion. We conclude that there are
few, if any,“long‐lived” IgG2a molecules present in the serum of C57BL/6 mice under …
Abstract
The concentration of IgG2a in the serum of C57BL/6 mice suppressed for the production of IgG2a was measured over a period of 3 months after suppression. The elimination of a minimum of 96% of the endogenous IgG2a molecules from the serum follows an exponential decay with a half‐life of 6–8 days. A monoclonal IgG2a antibody injected into suppressed or normal mice is eliminated from the serum in the same fashion. We conclude that there are few, if any, “long‐lived” IgG2a molecules present in the serum of C57BL/6 mice under physiological conditions.
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