The innate immune system recognizes microbial components through pattern‐recognition receptors (PRRs), including membrane‐bound Toll‐like receptors and cytosolic receptors such as RIG‐I‐like receptors and deoxyribonucleic acid (DNA) sensors. These PRRs trigger distinct signal transduction pathways that culminate in induction of an array of cytokines and other mediators required for host defense. The tripartite motif (TRIM) family is a diverse family of RING finger domain‐containing proteins, which are involved in a variety of cellular functions. Importantly, recent studies have shown that they are also involved in the regulation of innate immune responses through the modulation of PRR signalling pathways.