Targeting mutagenesis in B cells: Phosphorylation goes beyond AID association
Y Mu, KM McBride - Molecular & cellular oncology, 2018 - Taylor & Francis
Y Mu, KM McBride
Molecular & cellular oncology, 2018•Taylor & FrancisThe mutations induced by activation-induced cytidine deaminase (AID) trigger antibody
diversification but can cause genome instability. We find that AID phosphorylation is an
important determinant of “off-target” mutagenesis and identify a drug that increases this
activity. These studies demonstrate how dysregulating AID phosphorylation can promote
oncogenesis.
diversification but can cause genome instability. We find that AID phosphorylation is an
important determinant of “off-target” mutagenesis and identify a drug that increases this
activity. These studies demonstrate how dysregulating AID phosphorylation can promote
oncogenesis.
Abstract
The mutations induced by activation-induced cytidine deaminase (AID) trigger antibody diversification but can cause genome instability. We find that AID phosphorylation is an important determinant of “off-target” mutagenesis and identify a drug that increases this activity. These studies demonstrate how dysregulating AID phosphorylation can promote oncogenesis.
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