[HTML][HTML] Stabilization of a prion strain of synthetic origin requires multiple serial passages
N Makarava, GG Kovacs, R Savtchenko… - Journal of Biological …, 2012 - ASBMB
Transmission of prions to a new host is frequently accompanied by strain adaptation, a
phenomenon that involves reduction of the incubation period, a change in
neuropathological features and, sometimes, tissue tropism. Here we show that a strain of
synthetic origin (SSLOW), although serially transmitted within the same species, displayed
the key attributes of the strain adaptation process. At least four serial passages were
required to stabilize the strain-specific SSLOW phenotype. The biological titration of SSLOW …
phenomenon that involves reduction of the incubation period, a change in
neuropathological features and, sometimes, tissue tropism. Here we show that a strain of
synthetic origin (SSLOW), although serially transmitted within the same species, displayed
the key attributes of the strain adaptation process. At least four serial passages were
required to stabilize the strain-specific SSLOW phenotype. The biological titration of SSLOW …