[HTML][HTML] Discriminating scrapie and bovine spongiform encephalopathy isolates by infrared spectroscopy of pathological prion protein
A Thomzig, S Spassov, M Friedrich, D Naumann… - Journal of Biological …, 2004 - ASBMB
For the surveillance of transmissible spongiform encephalopathies (TSEs) in animals and
humans, the discrimination of different TSE strains causing scrapie, BSE, or Creutzfeldt-
Jakob disease constitutes a substantial challenge. We addressed this problem by Fourier
transform-infrared (FT-IR) spectroscopy of pathological prion protein PrP27–30. Different
isolates of hamster-adapted scrapie (263K, 22A-H, and ME7-H) and BSE (BSE-H) were
passaged in Syrian hamsters. Two of these agents, 22A-H and ME7-H, caused TSEs with …
humans, the discrimination of different TSE strains causing scrapie, BSE, or Creutzfeldt-
Jakob disease constitutes a substantial challenge. We addressed this problem by Fourier
transform-infrared (FT-IR) spectroscopy of pathological prion protein PrP27–30. Different
isolates of hamster-adapted scrapie (263K, 22A-H, and ME7-H) and BSE (BSE-H) were
passaged in Syrian hamsters. Two of these agents, 22A-H and ME7-H, caused TSEs with …