[HTML][HTML] Proteomic analysis of NCK1/2 adaptors uncovers paralog-specific interactions that reveal a new role for NCK2 in cell abscission during cytokinesis
K Jacquet, SL Banerjee, FJM Chartier, S Elowe… - Molecular & Cellular …, 2018 - ASBMB
Signals from cell surface receptors are often relayed via adaptor proteins. NCK1 and NCK2
are Src-Homology (SH) 2 and 3 domain adaptors that regulate processes requiring a
remodeling of the actin cytoskeleton. Evidence from gene inactivation in mouse suggests
that NCK1 and NCK2 are functionally redundant, although recent reports support the idea of
unique functions for NCK1 and NCK2. We sought to examine this question further by
delineating NCK1-and NCK2-specific signaling networks. We used both affinity purification …
are Src-Homology (SH) 2 and 3 domain adaptors that regulate processes requiring a
remodeling of the actin cytoskeleton. Evidence from gene inactivation in mouse suggests
that NCK1 and NCK2 are functionally redundant, although recent reports support the idea of
unique functions for NCK1 and NCK2. We sought to examine this question further by
delineating NCK1-and NCK2-specific signaling networks. We used both affinity purification …