Atherothrombosis is the leading cause of morbidity and mortality in patients with diabetes
mellitus. Several mechanisms contribute to the diabetic prothrombotic state, including
endothelial dysfunction, coagulative activation and platelet hyper-reactivity. In particular,
diabetic platelets are characterised by dysregulation of several signaling pathways leading
to enhanced adhesion, activation and aggregation. These alterations result from the
interaction among hyperglycemia, insulin resistance, inflammation and oxidative stress. This …