Evidence that Alzheimer's disease is a microvascular disorder: the role of constitutive nitric oxide
JC De la Torre, GB Stefano - Brain research reviews, 2000 - Elsevier
Evidence is fast accumulating which indicates that Alzheimer's disease is a vascular
disorder with neurodegenerative consequences rather than a neurodegenerative disorder
with vascular consequences. It is proposed that two factors need to be present for AD to
develop:(1) advanced ageing,(2) presence of a condition that lowers cerebral perfusion,
such as a vascular-risk factor. The first factor introduces a normal but potentially insidious
process that lowers cerebral blood flow in inverse relation to increased ageing; the second …
disorder with neurodegenerative consequences rather than a neurodegenerative disorder
with vascular consequences. It is proposed that two factors need to be present for AD to
develop:(1) advanced ageing,(2) presence of a condition that lowers cerebral perfusion,
such as a vascular-risk factor. The first factor introduces a normal but potentially insidious
process that lowers cerebral blood flow in inverse relation to increased ageing; the second …