OBJECTIVE: Atherosclerosis is associated with Alzheimer's disease (AD) in humans, but the
nature of this link is still elusive. Aim of this study was to investigate aortic atherosclerosis
development in a mouse model with central nervous system (CNS) restricted β-amyloid
precursor protein (APP) overexpression. METHODS AND RESULTS: APP23 mice,
overexpressing the Swedish mutated human APP selectively in the brain, were crossed with
mice lacking apolipoprotein E (ApoE KO). Nine weeks old mice were fed a western type diet …