Hypoxia is a state where oxygen availability/delivery is below the level necessary to
maintain physiological oxygen tension for a particular tissue. It is well-established that when
tissue demand exceeds its oxygen supply, a cascade of intracellular events is activated, with
the elevation of the expression of hypoxia-inducible factors (HIFs). As a consequence, the
extensive transcriptional response regulating angiogenesis, glucose metabolism, cell
growth, metastasis and others processes is induced. The discovery of differences between …